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目的:探讨腹腔镜与开放肾癌根治术对机体应激反应的影响。方法:66例肾癌患者随机分为观察组(n=33)与对照组(n=33),观察组给予腹腔镜下肾癌根治术,对照组给予开放肾癌根治术,对比两组患者机体应激反应情况。结果:两组患者术前血清皮质醇(COR)、心率、血压、白细胞计数(WBC)、C反应蛋白(CRP)和甲状腺素(FT3和FT4)比较均差异无统计学意义(P>0.05),术后第1天和第3天两组血清COR、WBC、CRP、心率和血压均显著增高(P<0.05),但观察组显著低于对照组(P<0.05);两组FT3和FT4在术后第1天和第3天均显著降低,但观察组显著高于对照组(P<0.05)。结论:腹腔镜肾癌根治术与开放肾癌根治术均可使机体产生一系列应激反应,但腹腔镜肾癌根治术机体应激反应小,患者恢复快,值得推广。
Objective: To investigate the effect of laparoscopy and open radical nephrectomy on stress response in vivo. Methods: 66 patients with renal cell carcinoma were randomly divided into observation group (n = 33) and control group (n = 33). The observation group received laparoscopic radical nephrectomy and the control group received open radical nephrectomy. Body stress response. Results: There was no significant difference in COR, heart rate, blood pressure, WBC, CRP and FT3 between the two groups before operation (P> 0.05) The levels of COR, WBC, CRP, heart rate and blood pressure in the two groups were significantly increased on the first day and the third day after operation (P <0.05), but the levels in the observation group were significantly lower than those in the control group (P <0.05) On the first day and the third day after operation, they both decreased significantly, but the observation group was significantly higher than that of the control group (P <0.05). Conclusion: Laparoscopic radical nephrectomy and open radical nephrectomy can cause a series of stress responses in the body. However, the response to laparoscopic radical nephrectomy is small and the patients recover quickly and are worth popularizing.