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目的探讨血清降钙素原(PCT)测定对支气管哮喘急性发作患者抗生素使用的指导价值。方法将55例支气管哮喘急性发作期患者随机分为两组,观察组35例根据血清降钙素素原水平指导用药,对照组20例按照支气管哮喘防治指南进行抗生素治疗。对比两组患者的住院时间、住院费用、抗生素使用率及不同患者的使用情况、治疗有效率。结果两组患者住院时间差异比较无统计学意义P>0.05;观察组患者住院费用明显少于对照组P<0.01;观察组抗生素使用率低于对照组,但组间差异无统计学意义P>0.05,两组间临床治疗有效率和随访1个月的复发率比较均无统计学意义P>0.05;观察组患者重度-重危与组内轻度-中度比较差异有统计学意义P<0.05,对照组组内比较无统计学意义P>0.05;两组间轻度-中度和重度-重危分别比较差异均无统计学意义P>0.05。结论 PCT是支气管哮喘急性发作期存在细菌感染的血清标志物,PCT检测对患者临床抗生素用药具有较高的指导价值。
Objective To investigate the value of serum procalcitonin (PCT) determination in the use of antibiotics in patients with acute exacerbation of bronchial asthma. Methods Fifty-five patients with acute exacerbation of bronchial asthma were randomly divided into two groups. 35 cases in the observation group were guided by serum procalcitonin level, and 20 cases in the control group were treated with antibiotics according to the guidelines of prevention and treatment of bronchial asthma. The two groups of patients were compared in hospitalization, hospitalization costs, antibiotic use and the use of different patients, the treatment efficiency. Results There was no significant difference in hospitalization time between the two groups (P> 0.05). The hospitalization cost of the observation group was significantly less than that of the control group (P <0.01). The antibiotic utilization rate of the observation group was lower than that of the control group, but there was no significant difference between groups 0.05, there was no significant difference between the two groups in clinical treatment efficiency and follow-up one month recurrence rate P> 0.05; the observation group of patients with severe - severe and mild intra-group difference was statistically significant P < 0.05, there was no statistical significance in the control group (P> 0.05). There was no significant difference between the two groups in the mild-moderate and severe-severe cases, P> 0.05. Conclusions PCT is a serum marker of bacterial infection in acute exacerbation of bronchial asthma. PCT test has high guiding value for clinical antibiotics in patients.