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目的 了解药物性肝病及胃肠粘膜损伤的流行情况。方法 采用整群分层随机抽样方法对浙北地区8所医院收治的 2 87例药物性肝病及胃肠粘膜损伤患者的流行特征和相关因素进行分析。结果 药物性肝病及胃肠粘膜损伤发生率为 1 2 4 % ,男性多于女性 ,中青年发生率高 ,致肝病的药物种类多于致胃肠粘膜损伤的药物种类 ,医疗费用高于对照组。结论 药物性肝病及胃肠粘膜损伤影响了当地人群的健康 ,研究结果可为卫生行政部门制订临床药物毒副作用的监察和控制政策提供参考依据。
Objective To understand the prevalence of drug-induced liver disease and gastrointestinal mucosal injury. Methods The cluster stratified random sampling method was used to analyze the epidemiological characteristics and related factors of 2 87 patients with drug-induced liver disease and gastrointestinal mucosal injury admitted to 8 hospitals in north Zhejiang. Results The incidence of drug-induced liver disease and gastrointestinal mucosal injury was 122.4%. There were more males than females, high incidence of middle-aged and young people, more drug-induced liver diseases than that of gastrointestinal mucosal injury, and the medical expenses were higher than those of the control group . Conclusion Drug-induced liver disease and gastrointestinal mucosal injury affect the health of local population. The results of this study may provide reference for the health administration to monitor and control the side effects of clinical drugs.