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目的:研究托吡酯(topiramate,TPM)与苯巴比妥(phenobarbital,PB)对小儿癫痫(Epilepsy)患儿发作次数及痫样放电的影响。方法:将我院2010年8月至2013年8月入院接受诊治的200例癫痫患儿作为观察对象,随机分成两组。观察组采用TPM治疗,对照组采用PB治疗。对比两组患儿治疗前以及治疗后3个月癫痫发作次数、疗效以及不良反应情况。结果:观察组部分性发作减少次数、全身性发作减少次数及总发作减少次数,均显著高于对照组;观察组治愈率、愈显率、总有效率,均显著高于对照组;观察组不良反应情况显著少于对照组;差异均具有统计学意义(均P<0.05)。结论:与PB相比,TPM治疗小儿癫痫疗效更佳,且不良反应更少,值得临床推荐。
Objective: To study the effects of topiramate (TPM) and phenobarbital (PB) on the number of epileptic episodes and epileptiform discharges in children with epilepsy. Methods: 200 cases of epilepsy admitted to our hospital from August 2010 to August 2013 were enrolled in this study. Patients were randomly divided into two groups. The observation group treated with TPM, the control group treated with PB. The frequency of seizures, the curative effect and the adverse reactions of the two groups before treatment and 3 months after treatment were compared. Results: The number of partial seizures, the number of generalized seizures and the number of total seizures in the observation group were significantly higher than those in the control group. The cure rate, the curettage rate and the total effective rate in the observation group were significantly higher than those in the control group. The observation group Adverse reactions were significantly less than the control group; the differences were statistically significant (P <0.05). Conclusion: Compared with PB, TPM is more effective in treatment of epilepsy in children with less adverse reactions, which is worthy of clinical recommendation.