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目的:探讨血浆同型半胱氨酸(HCY)、D-二聚体(D-D)、超敏C-反应蛋白(hs-CRP)水平变化与妊娠期高血压疾病(以下简称妊高征)发生、发展间的关系。方法:检测118例妊高征患者及116名同孕周正常单胎妊娠妇女的血浆HCY、D-D、hs-CRP水平,并进行比较,分析其变化的意义。将妊高征组按血压水平分为4个亚组,妊娠高血压者15例;轻度子痫间前期48例;重度子痫间前期42例;子痫间13例,组间两两比较以上3个指标。结果:妊高征患者与正常孕妇比较,其血浆HCY、D-D、hs-CRP水平差异均有统计学意义(P<0.05);妊高征患者按血压的亚分组中(4个亚分组),组间两两比较3项指标,差异均有统计学意义(P<0.05),且随着妊高征病情的发展,这3项指标均呈逐渐升高趋势。结论:HCY、D-D、hs-CRP联合检测对妊娠期高血压疾病早期诊断、了解病情变化及预后评估具有重要的临床意义。
Objective: To investigate the changes of plasma homocysteine (HCY), D-dimer (DD) and high-sensitivity C-reactive protein (hs-CRP) and the occurrence of hypertensive disorder complicating pregnancy (PIH) The relationship between development. Methods: The plasma levels of HCY, D-D and hs-CRP in 118 patients with PIH and 116 normal singleton pregnancies were detected and compared to analyze the significance of the changes. According to the level of blood pressure, the patients with PIH were divided into 4 subgroups according to the blood pressure level, 15 cases of pregnancy-induced hypertension, 48 cases of mild preeclampsia, 42 cases of severe preeclampsia and 13 cases of eclampsia. The above three indicators. Results: The differences of plasma HCY, DD, hs-CRP levels between the PIH patients and the normal pregnant women were statistically significant (P <0.05). Among the subgroups (4 sub-groups) of PIH patients, There were statistically significant differences between the two groups (P <0.05), and with the development of PIH, the three indicators showed a gradual upward trend. Conclusion: The combined detection of HCY, D-D and hs-CRP has important clinical significance for the early diagnosis of hypertensive disorder complicating pregnancy and the understanding of the changes of disease and prognosis.