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犬在体实验表明,活血化瘀注射液静脉内注射可增加肠血流,给药前平均值为181.56±62.38ml.min~(-1),给药后20、40及60分钟分别为291.22±98.12、307.56±106.64及283.33±96.84ml.min~(-1),差别非常显著。它还能增加肠组织氧耗,给药前为4.85±2.23ml.min~(-1),给药后相应时间分别为6.97±3.62、6.97±3.80及7.11±3.04ml.min~(-1),差别显著或非常显著,P<0.05或 P<0.01。结果提示,改善血流并增加组织氧耗可能是应用活血化瘀治则治疗急腹症的重要药理基础。
Dogs in vivo experiments showed that the blood injection of Huoxue Huayu Injection can increase intestinal blood flow, with an average value of 181.56±62.38ml.min~(-1) before administration, and 291.22 at 20, 40, and 60 minutes after administration. ±98.12, 307.56±106.64 and 283.33±96.84 ml.min~(-1), the difference is very significant. It also increased intestinal oxygen consumption, 4.85±2.23 ml.min~(-1) before administration, and 6.97±3.62, 6.97±3.80, and 7.11±3.04 ml.min~(-1) after administration, respectively. ), the difference was significant or very significant, P<0.05 or P<0.01. The results suggest that improving blood flow and increasing tissue oxygen consumption may be an important pharmacological basis for the treatment of acute abdomen with the treatment of activating blood circulation and removing blood stasis.