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目的:研究持续热灌注腹腔化疗联合静脉化疗治疗进展期胃肠肿瘤的临床效果。方法:选取我院2010年2月至2013年11月收治的60例进展期胃肠肿瘤患者为研究对象,随机分为对照组和观察组,各30例。对照组采取常规腹腔化疗联合静脉化疗治疗,观察组实行持续热灌注腹腔化疗联合静脉化疗治疗,对两组患者化疗效果及并发症等进行对比分析。结果:观察组完全缓解9例(30%),部分缓解12例(40%)治疗总有效率70%;对照组完全缓解4例(13.33%),部分缓解6例(20%),治疗总有效率33.33%,两组差异有统计学意义,P<0.05。治疗后两组患者生活质量均有所改善,观察组明显高于对照组,P<0.05。此外两组患者治疗后毒副作用无明显差异,P>0.05。结论:持续热灌注腹腔化疗联合静脉化疗治疗进展期胃肠肿瘤疗效显著,能有效改善患者生活质量,安全有效,可临床进一步应用。
Objective: To study the clinical effect of continuous thermal perfusion intraperitoneal chemotherapy combined with intravenous chemotherapy in the treatment of advanced gastrointestinal tumors. Methods: Sixty patients with advanced gastrointestinal cancer who were admitted to our hospital from February 2010 to November 2013 were selected as study subjects and randomly divided into control group and observation group, with 30 cases in each group. The control group was treated with conventional intraperitoneal chemotherapy combined with intravenous chemotherapy. The observation group was given continuous thermal perfusion intraperitoneal chemotherapy combined with intravenous chemotherapy. The therapeutic effects and complications of the two groups were compared. Results: In the observation group, 9 cases (30%) were relieved completely and 12 cases (40%) partially relieved the total effective rate was 70%. In the control group, 4 cases (13.33%) were completely relieved and 6 cases (20% The effective rate was 33.33%, the difference between the two groups was statistically significant, P <0.05. After treatment, the quality of life of both groups improved, the observation group was significantly higher than the control group, P <0.05. In addition, the two groups of patients no significant difference in side effects after treatment, P> 0.05. Conclusion: Continuous peritoneal chemotherapy combined with intravenous chemotherapy in the treatment of advanced gastrointestinal tumors has significant curative effect, which can effectively improve the quality of life of patients, is safe and effective and can be further applied clinically.