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30 October 2018rn? 2018 Huazhong University of Science and TechnologyrnAccording to Dr. Jeffrey Stanaway, worldwide, 1.45 million lives were lost to viral hepatitis in 2013, which was significantly greater than the 0.89 million deaths in 1990. Among all viral hepatitis-related morbidity cases, the prevalence of hepatitis C infection-related morbidity was the highest [1]. It has been well known that hepatitis-related mortality is influenced by geographical variation;Oceania, western-sub-Saharan Africa, and central Asia have the highest mortality rate. Not surprisingly, East Asia and South Asia have the highest absolute numbers because of their large population [2]. Hepatitis-related cirrhosis is often observed in viral hepatitis patients as the sequential progression. Scientists have long believed that there is a close association between hepatitis-related cirrhosis and hepatocellular carcinoma (HCC) although there is no comprehensive understanding yet. HCC is the most common primary liver cancer with a complex etiology and has mechanisms that make early clinical detection and treatment of this disease challenging. As one of the most critical risk factors for HCC, viral hepatitis and hepatitis-related cirrhosis deserve more attention