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目的 探讨术中埋置在残瘤腔间质内化疗囊和Ommaya囊对 31例恶性脑胶质瘤患者行同步间质内放疗 (interstitialbrachytherapty)间质内化疗、 (interstitialchemotherapty)的疗效。方法 于术中尽可能多的切除肿瘤并在残瘤腔内埋置3 2 P放疗囊和Ommaya囊 ,并做化疗药物体外敏感检测后选择高抑制率化疗药物 ,术后同步进行经皮穿刺注入3 2 P及敏感化疗药物。结果 能明显延长患者的生存期及改善生存质量 ,31例患者 1年生存 2 2例 (71% )、 2年生存 2 0例 (6 5 % )、 3年生存 19例 (6 1% )。结论 同步间质内放疗、内化疗能有效抑制肿瘤生长 ,控制复发 ,延长生存期 ,改善生存质量 ,是一种可供选择的综合治疗胶质瘤的有效的方法。
Objective To investigate the effect of interstitial intramuscular irradiation (interstitial brachytherapty) interstitial chemotherapy in 31 patients with malignant gliomas undergoing intraoperative chemotherapy and Ommaya capsules. Methods To excise the tumor as much as possible and implant the 3 2 P radiotherapy capsule and Ommaya capsule in the residual tumor cavity and select the chemotherapeutic drugs with high inhibitory rate after in vitro sensitive detection. After the surgery, the percutaneous puncture injection 3 2 P and sensitive chemotherapeutic drugs. Results The survival time and quality of life of patients were significantly prolonged. Twenty-one patients (21%) survived 2 years (71%), 2 years survived 20% (65%) and 3 years survived 19 patients (61%). Conclusions It is an effective and effective method to treat glioma with synchronous interstitial radiotherapy and internal chemotherapy, which can effectively inhibit tumor growth, control recurrence, prolong survival and improve quality of life.