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目的:观察PCOS患者促排卵治疗后着床窗口期子宫内膜NF-κB和Galectin-3的表达。方法:选择2010年8月～2011年1月郑州大学第三附属医院PCOS患者12例(PCOS组),选择同期其他原因不孕妇女自然周期11例(对照组),着床窗口期取子宫内膜进行NF-κB和Galectin-3免疫组化染色,并进行统计学分析。结果:PCOS组着床窗口期子宫内膜NF-κB和Galectin-3表达均低于对照组(P<0.01)。结论:PCOS患者的着床窗口期子宫内膜呈现NF-κB和Galectin-3低表达,可能使子宫内膜容受性下降,与PCOS患者内分泌紊乱纠正后仍出现妊娠率低、流产率高的不良妊娠结局有关。
OBJECTIVE: To observe the expression of NF-κB and Galectin-3 in the implantation window after ovulation induction in patients with PCOS. Methods: From August 2010 to January 2011, 12 patients with PCOS in the Third Affiliated Hospital of Zhengzhou University (PCOS group) were enrolled in this study. Eleven patients (control group) with infertile women of other causes during the same period were selected. Membrane for NF-κB and Galectin-3 immunohistochemical staining and statistical analysis. Results: The expression of NF-κB and Galectin-3 in the endometrium of PCOS group was lower than that of the control group (P <0.01). CONCLUSIONS: The low expression of NF-κB and Galectin-3 in implantation window of endometrial PCOS patients may decrease the endometrial receptivity, and the pregnancy rate and abortion rate still appear after the correction of endocrine disorders in patients with PCOS Bad pregnancy outcome.