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目的：探讨肺癌中ｐ５３蛋白表达与临床病理的关系。方法：应用免疫组织化学ｓ－ｐ法对１２９例肺癌组织标本进行ｐ５３蛋白检测。结果：ｐ５３蛋白阳性表达率为５２．７％，其表达与组织学分型分级无关，仅在腺癌组内与淋巴结有无癌转移有关（Ｐ＜０．０５），半年以内死亡组与５年以上生存组之间有显著性差异（Ｐ＜０．０５）。结论：ｐ５３蛋白表达能够反映肿瘤的生物学特性，并可作为评估肿瘤预后的有效指标。
Objective: To investigate the relationship between the expression of p53 protein and clinical pathology in lung cancer. Methods: The p53 protein was detected in 129 lung cancer specimens by immunohistochemical s-p method. RESULTS: The positive expression rate of p53 protein was 52.7%. The expression of p53 protein was not associated with the histological type and grade. It was only related to the presence or absence of cancer metastasis in the adenocarcinoma group (P<0.05). Within 5 months, the death group and 5 years were found. There was a significant difference between the above survival groups (P<0.05). Conclusion: The expression of p53 protein can reflect the biological characteristics of tumors, and it can be used as an effective index to evaluate the prognosis of tumors.