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目的对比有无高危因素葡萄胎患者临床特点及治疗效果,总结临床治疗体会。方法对200例葡萄胎患者的临床资料进行回顾性分析,对比有无高危恶变因素患者临床症状表现、恶变率、预防性化疗缓解率等,总结有无高危因素葡萄胎患者临床特点与治疗效果。结果 200例患者中恶变患者58例(29.0%),伴有典型高危因素患者有46例(79.3%),无高危恶变因素患者12例(20.7%),含有高危因素患者恶变率显著高于无高危恶变因素患者,差异具有统计学意义(P<0.05)。结论葡萄胎患者恶变率与子宫大小、血清HCG水平、子宫大小、卵巢黄素囊肿等高危因素密切相关,临床治疗中要结合高危因素做正确评估针对性实施预防性化疗,从而控制患者病情进展,提升疗效与患者生存质量。
Objective To compare the clinical characteristics and therapeutic effect of patients with moles with or without risk factors and to summarize the experience of clinical treatment. Methods The clinical data of 200 patients with hydatidiform mole were retrospectively analyzed. The clinical symptoms, malignant transformation rate and preventive chemotherapy response rate were compared between patients with and without high risk malignant factors. The clinical features and therapeutic effects were analyzed. Results There were 58 patients (29.0%) with malignant transformation in 200 patients, 46 patients (79.3%) with typical risk factors and 12 (20.7%) patients without high-risk malignant disease. The patients with high-risk factors were significantly higher than those without Patients with high risk of malignant transformation, the difference was statistically significant (P <0.05). Conclusions The rate of malignant transformation in patients with hydatidiform mole is closely related to the high risk factors such as uterine size, serum HCG level, uterine size and ovarian flavin cyst. In clinical treatment, we should evaluate the targeted preventive chemotherapy in combination with risk factors so as to control the progression of the disease, Improve efficacy and quality of life of patients.