Full-length clone and characterization of a human immunodeficiency virus type 1 subtype B' isol

来源 :Chinese Medical Journal | 被引量 : 0次 | 上传用户:lj200610819
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There are two types of Human ImmunodeficiencyVirus(HIV):HIV-1 and HIV-2.HIV-1 dominatesepidemics in many different parts of the world,and HIV-2is principally responsible for the epidemic in westernAfrica.In China,Zeng et al~1 have reported the firstindividual infected with HIV-1 in 1985.And in the 1990s,there was a severe epidemic involving the HIV-1 B’strainamong people who sold blood and plasma in Henan,Hubei and adjacent provinces.~2 To further study inHIV/AIDS vaccines and HIV-1 drug resistance for peoplein these regions,we need to construct an infectious HIV-1B’molecular clone which is representative of the virus inthese areas.~3 To this end,we have isolated a HIV-1 B’virus from a child who was infected with HW-1 from his There are two types of Human Immunodeficiency Virus (HIV): HIV-1 and HIV-2.HIV-1 dominatesepidemics in many different parts of the world, and HIV-2is principally responsible for the epidemic in westernAfrica.In China, Zeng et al ~ 1 have reported the first in- dividual infected with HIV-1 in 1985. And in the 1990s, there was a severe epidemic involving the HIV-1 B’strainamong people who sold blood and plasma in Henan, Hubei and adjacent provinces. ~ 2 To further study inHIV / AIDS vaccines and HIV-1 drug resistance for peoplein these regions, we need to construct an infectious HIV-1B’molecular clone which is representative of the virus inthese areas. ~ 3 To this end, we have isolated a HIV-1 B ’virus from a child who was infected with HW-1 from his
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