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据报道,组织胺对多种免疫功能产生影响,这包括致分裂原和抗原诱导的T细胞增殖、抗体的产生、T细胞介导的细胞毒作用,NK细胞活性以及IL-2和IFN-γ的产生等等。本文对组织胺影响IL-2和IFN-γ产生的机制作了进一步的探讨。作者从健康供血者外周血中分离获得单个核细胞,然后用多克隆的T细胞激活剂萄葡球菌肠毒素A(SEA)诱导产生IL-2和IFN-γ。结果发现,当在培养液中加入浓度
Histamine has been reported to affect a variety of immune functions including mitogenic and antigen-induced T cell proliferation, antibody production, T cell mediated cytotoxicity, NK cell activity, and IL-2 and IFN- [gamma] And so on. In this paper, the mechanism by which histamine affects the production of IL-2 and IFN-γ is further explored. The authors isolated mononuclear cells from peripheral blood of healthy blood donors and then induced the production of IL-2 and IFN-γ with polyclonal T cells activated with S.aureus enterotoxin A (SEA). As a result, it was found that the concentration was added to the culture broth