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目的探讨LIN28B在宫颈上皮病变组织中表达与高危型人乳头状瘤病毒(HR-HPV)感染的关系及临床意义。方法应用免疫组化方法检测102例宫颈癌、83例宫颈上皮内瘤变(CIN)及33例宫颈炎组织中LIN28B表达情况,同时于术前采用第二代基因杂交捕获法(HC-Ⅱ)检测患者HR-HPV感染情况。对随访3年以上宫颈癌患者进行生存分析。结果 LIN28B在宫颈癌中高表达率均高于CIN和宫颈炎(P<0.05)。LIN28B表达与组织学分级、FIGO分期、浸润深度及淋巴结是否转移有关(P<0.05)。HR-HPV在宫颈炎、CIN和宫颈癌中感染率依次升高(P<0.05),但与临床病理参数均无关(P>0.05)。LIN28B表达与HR-HPV感染呈正相关(P<0.05)。LIN28B表达与预后有关(P<0.05),而HR-HPV感染与预后无关(P>0.05)。结论 LIN28B表达和HR-HPV感染可反映宫颈上皮病变的程度,联合检测二者有助于宫颈癌筛查及临床病理因素的判断,LIN28B表达与宫颈癌患者的预后密切相关。
Objective To investigate the relationship between the expression of LIN28B in high-risk human papillomavirus (HR-HPV) and its clinical significance in cervical epithelial lesions. Methods The expression of LIN28B in 102 cases of cervical cancer, 83 cases of cervical intraepithelial neoplasia (CIN) and 33 cases of cervicitis was detected by immunohistochemistry. The second generation hybridization capture method (HC-Ⅱ) Detection of HR-HPV infection in patients. Survival analysis of cervical cancer patients who were followed up for more than 3 years. Results The high expression rate of LIN28B in cervical cancer was higher than that of CIN and cervicitis (P <0.05). The expression of LIN28B was correlated with histological grade, FIGO stage, depth of invasion and lymph node metastasis (P <0.05). The infection rate of HR-HPV in cervicitis, CIN and cervical cancer increased successively (P <0.05), but had no correlation with clinicopathological parameters (P> 0.05). LIN28B expression was positively correlated with HR-HPV infection (P <0.05). The expression of LIN28B was correlated with prognosis (P <0.05), but HR-HPV infection had no relationship with prognosis (P> 0.05). Conclusion The expression of LIN28B and HR-HPV infection can reflect the degree of cervical epithelial lesions. The combined detection of cervical lymph node metastasis and cervical lymph node metastasis can be helpful for the screening of cervical cancer and clinicopathological factors. The expression of LIN28B is closely related to the prognosis of cervical cancer.