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目的 探讨干扰素治疗对慢性乙型肝炎患者外周血ＴＣ和Ｔｓ细胞状忘的影响，并分析干扰素疗效与Ｔｃ和Ｔｓ细胞变化的关系。方法 用双重染色免疫细胞学技术检测３２例干扰素治疗慢性乙型肝炎患者外周血ＴＣ和Ｔｓ细胞。结果 有２１例患者达到完全或部分应答标准，其中９例为完全应答，１２例为部分应答，１１例无应答；干扰素治疗结束时产生完全或部分应答组，Ｔｃ细胞水平较正常对照组均显著增高，Ｔｓ细胞水平均显著低于正常对照组；完全应答与部分应答组之间Ｔｃ和Ｔｓ细胞间的差异无显著性；无应答组Ｔｃ与完全或部分应答组相比，差异无显著性，而Ｔｓ细胞均显著高于后两组、结论 慢性乙型肝炎患者干扰素治疗可以导致患者体内Ｔｃ和Ｔｓ细胞水平Ｓ发生变化，其中尤以Ｔｓ细胞的变化更为明显，Ｔｓ水平的改变可能与干扰素抗病毒疗效的关系更为密切。
Objective To investigate the effects of interferon on TC and Ts cells in patients with chronic hepatitis B and to analyze the relationship between interferon efficacy and Tc and Ts cell changes. Methods Dual-staining immunocytometry was used to detect the levels of TC and Ts in peripheral blood of 32 patients with chronic hepatitis B treated with interferon. Results Twenty-one patients achieved complete or partial response criteria, of which 9 were complete response, 12 were partial response and 11 had no response; the complete or partial response group at the end of interferon treatment resulted in a higher Tc cell level than the normal control group Significantly increased, Ts cell levels were significantly lower than the normal control group; Tc and Ts cells between the complete response and partial response group was no significant difference; non-response group Tc and complete or partial response group, the difference was not significant , While the Ts cells were significantly higher than the latter two groups, Conclusion Interferon therapy in patients with chronic hepatitis B can cause changes in patients with T and Ts Ts levels in cells, especially Ts cells changes more pronounced Ts changes may be And the effect of interferon antiviral more closely.