采用ＳＤ大鼠持续泵入人工重组肿瘤坏死因子。型（ｒｈ－ＴＮＦ－ａ），以６×１０￣５Ｕ·ｋｇ￣－１／ｄ速度作用７２ｈ，观察血浆及组织丙二醛（ＭＤＡ）含量，全血和组织超氧化物歧化酶（ＳＯＤ）活性，组织超弱发光和白细胞吞噬发光的变化。结果：血浆及组织ＭＤＡ含量明显增加，全血ＳＯＤ活性显著下降，组织ＳＯＤ活性所受影响较小，肾、肠组织超弱发光明显增强，白细胞吞噬发光无明显变化。实验表明：持续７２ｈ泵入ＴＮＦ作用于大鼠，可使机体自由基产生增加，自由基清除系统部分受损，而导致脂质过氧化损伤，但对分叶核粒细胞的呼吸爆发作用无明显影响。 SD rats were continuously pumped into artificial recombinant tumor necrosis factor. (Rh-TNF-a) at a speed of 6 × 10 ~ 5 U · kg ~ -1 / d for 72 hours. The contents of malondialdehyde (MDA), whole blood and tissue superoxide dismutase (SOD) Activity, tissue ultra-weak luminescence and leukocyte phagocytosis. Results: The content of MDA in plasma and tissue increased significantly, the activity of SOD in whole blood decreased significantly, the activity of SOD in the tissue was less affected, the ultraweak luminescence of kidney and intestine increased obviously, and the phagocytosis of leucocytes did not change obviously. Experiments show that: continued 72h pump TNF in rats, can increase the body’s free radicals, free radical scavenging system partially damaged, leading to lipid peroxidation injury, but on the lobular granulocytes respiratory burst effect was not obvious influences.