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目的:探讨肺炎患儿血小板参数和血液流变学指标的变化并观察复方香丹注射液对小儿肺炎的疗效和机制。方法:观察入选儿童血小板参数和血液流变学变化,肺炎患儿在常规治疗的基础上应用复方香丹注射液(复方香丹治疗组),进行疗效观察。结果:①血小板参数:与对照组比较,复方香丹治疗组肺炎急性期PLT和PDW升高,PCT降低(P<0.05);恢复期PLT和PDW增高(P<0.05);复方香丹治疗组患儿肺炎急性期与恢复期比较,PLT增加更显著(P<0.05)。②血液流变学:与对照组比较,复方香丹治疗组肺炎急性期血液流变学各项指标均升高(P<0.05);恢复期除全血黏度(高切)外,均有显著性变化(P<0.05);复方香丹治疗组肺炎急性期与恢复期比较,红细胞电泳和刚性指数变化不明显。③和常规治疗组患儿相比,复方香丹治疗组患儿住院时间明显缩短(P<0.05)。结论:肺炎患儿血小板参数和血液流变学的数据变化显示肺炎患儿存在血液黏度增高。复方香丹注射液可以改善患儿的血液黏滞程度、缩短患儿的住院时间、减轻家长的经济负担,值得临床推广。
Objective: To investigate the changes of platelet parameters and hemorheology in children with pneumonia and to observe the curative effect and mechanism of compound Xiangdan injection on pneumonia in children. Methods: The changes of platelet parameters and hemorheology in selected children were observed. The children with pneumonia were treated with compound Xiangdan injection (compound Xiangdan) on the basis of routine treatment, and the curative effect was observed. PLT and PDW increased in the acute phase of Pneumonia, PCT decreased (P <0.05), PLT and PDW increased in recovery phase (P <0.05) In children with acute and convalescent pneumonia, PLT increased more significantly (P <0.05). ② Hemorheology: Compared with the control group, the indicators of hemorheology in the acute phase of compound pneumonia were all increased (P <0.05), except for the whole blood viscosity (high-cut) (P <0.05). Compared with recovery period, the changes of erythrocyte electrophoresis and rigidity index in compound Xiangdan group were not obvious. ③Compared with the normal treatment group, the hospitalization time of the compound Xiangdan group was significantly shorter (P <0.05). Conclusions: Changes in platelet parameters and hemorheology in children with pneumonia show increased blood viscosity in children with pneumonia. Compound Xiangdan injection can improve children’s blood viscosity, shorten the hospitalization of children, reduce the financial burden on parents, it is worth clinical promotion.