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目的探讨持续静脉使用纳络酮治疗进展型脑梗死的临床疗效。方法将80例进展型脑梗死患者随机分为研究组与对照组,两组均给予对症支持等治疗,研究组在此基础上加用纳络酮治疗,日剂量8~12 mg,加入0.9%氯化钠注射液250 m l中24 h持续滴注,使用微量泵调控输液速度,疗程14 d,分别于治疗前后评估患者临床神经功能缺损程度和临床疗效。结果治疗后两组神经功能缺损评分均下降(P<0.01),治疗后研究组的评分比对照组更低(P<0.01),研究组临床疗效优于对照组(P<0.05)。结论持续静脉使用纳络酮治疗进展型脑梗死有较好的疗效。
Objective To investigate the clinical efficacy of continuous intravenous naloxone in the treatment of advanced cerebral infarction. Methods Eighty patients with progressive cerebral infarction were randomly divided into study group and control group. Both groups were given symptomatic treatment. The study group was treated with naloxone on the basis of daily dose of 8 ~ 12 mg, 0.9% Sodium chloride injection 250 ml 24 h continuous infusion, the use of micro-pump control infusion speed, treatment 14 d, respectively, before and after treatment to assess the clinical neurological deficit and clinical efficacy. Results After treatment, the scores of neurological deficit in both groups were decreased (P <0.01). After treatment, the score of the study group was lower than that of the control group (P <0.01). The clinical efficacy of the study group was better than that of the control group (P <0.05). Conclusion Continuous intravenous naloxone treatment of advanced cerebral infarction has a good effect.