[Objective] The aim was to explore antioxidation of proanthocyanidin from pine needles in the serum of mice, so as to provide reliable experimental support for its further development and utilization. [Method] Effects of different concentrations of proanthocyanidin from pine needles on SOD activity, MDA content and organ indexes of mice were compared through gastric perfusion. [Result] Compared with blank control group, SOD activity and MDA content of mice increased and decreased significantly (P<0.05) in treatment groups, respectively; while there was no significant difference in viscera indices of mice among treatment groups. [Conclusion] Proanthocyanidin from pine needles had antioxidative activity to a certain extent. [Objective] The aim was to explore antioxidation of proanthocyanidin from pine needles in the serum of mice, so as to provide experimental experimental support for its further development and utilization. [Method] Effects of different concentrations of proanthocyanidin from pine needles on SOD activity, MDA content and organ indexes of mice were compared with gastric perfusion. [Result] Compared with blank control group, SOD activity and MDA content of mice increased and decreased significantly (P <0.05) in treatment groups, respectively; while there was no significant difference in viscera indices of mice among treatment groups. [Conclusion] Proanthocyanidin from pine needles had antioxidative activity to a certain extent.