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目的:探讨早期宫颈鳞癌组织中PTEN和survivin的表达与淋巴结转移的关系。方法:应用免疫组化S-P法检测45例宫颈上皮内瘤变、45例无腹膜后淋巴结转移宫颈鳞癌、35例有腹膜后淋巴结转移宫颈鳞癌3组组织中PTEN和Survivin的阳性表达水平。结果:PTEN在宫颈上皮内瘤变、无腹膜后淋巴结转移宫颈鳞癌、有腹膜后淋巴结转移宫颈鳞癌组织中表达的平均光密度值(A)分别为:0.346±0.038、0.226±0.029、0.159±0.041,PTEN的表达递减(P<0.05)。Survivin在三组组织中的平均光密度值(A)分别为:0.163±0.017、0.247±0.018、0.336±0.051,Survivin的表达递增(P<0.05)。结论:PTEN表达下调,Survivin表达上调,二者的表达呈负相关性,与宫颈鳞癌的淋巴结转移行为密切相关。
Objective: To investigate the relationship between PTEN and survivin expression and lymph node metastasis in early stage of cervical squamous cell carcinoma. Methods: The positive expression of PTEN and Survivin in 45 cases of cervical intraepithelial neoplasia, 45 cases of cervical squamous cell carcinoma without retroperitoneal lymph node metastasis and 35 cases of cervical squamous cell carcinoma of retroperitoneal lymph node metastasis were detected by immunohistochemical S-P method. Results: The average optical density (A) of PTEN expression in cervical intraepithelial neoplasia without cervical cancer with retroperitoneal lymph node metastasis and cervical squamous cell carcinoma with retroperitoneal lymph node metastasis (A) were 0.346 ± 0.038,0.226 ± 0.029,0.159 ± 0.041, PTEN decreased (P <0.05). Survivin in the three groups of the average optical density (A) were 0.163 ± 0.017,0.247 ± 0.018,0.336 ± 0.051, Survivin expression increased (P <0.05). Conclusion: The expression of PTEN is down-regulated and the expression of Survivin is up-regulated. The expression of PTEN is negatively correlated with lymph node metastasis of cervical squamous cell carcinoma.