具有高免疫球蛋M血症的免疫缺陷是一种综合征,其特征为血清IgM水平由正常至升高,IgG及IgA降低或缺无。此综合征被认为是B淋巴细胞有缺陷,可能是免疫球蛋白中不能进行由lgM向IgG或IgA的转移。为了更直接论述这一问题,我们用美洲商陆有丝分裂原培养了9名患此综合征病人的B细胞的“转移”T细胞或者正常对照T细胞,在有正常T细胞的培养物 An immunodeficiency with high immunoglobulin M is a syndrome characterized by a change in serum IgM levels from normal to elevated, with reduced or absent IgG and IgA. This syndrome is thought to be defective in B lymphocytes, probably due to inability of immunoglobulins to transfer lgM to IgG or IgA. To address this issue more directly, we cultured nine “metastatic” T cells or normal control T cells from B cells of this patient with Meriones ploysia in a culture of normal T cells