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目的探讨妊娠期急性脂肪肝(AFLP)的临床表现、诊断、治疗及预后。方法对2009年1月至2012年6月濮阳油田总医院收治的7例妊娠期急性脂肪肝患者的临床资料进行回顾性分析。结果本组资料7例患者首发症状均为消化道症状,短期内可出现不同程度的肝肾功能损伤及凝血功能障碍,严重时可发生弥漫性血管内凝血及多脏器损伤。结论提高产科大夫对该病的诊断意识,早期诊断,尽快终止妊娠,多科协作,积极有效的支持治疗是改善母儿预后的关键。治疗条件不具备时尽快转诊。
Objective To investigate the clinical manifestations, diagnosis, treatment and prognosis of acute fatty liver during pregnancy (AFLP). Methods The clinical data of 7 patients with acute fatty liver during pregnancy admitted to Puyang Oilfield General Hospital from January 2009 to June 2012 were analyzed retrospectively. Results The first group of 7 cases of patients with gastrointestinal symptoms were symptoms of short-term may have varying degrees of liver and kidney dysfunction and coagulation disorders, severe cases can occur diffuse intravascular coagulation and multiple organ injury. Conclusions The key to improving prognosis of maternal and infant is to improve the awareness of obstetrics and gynecology on diagnosis of the disease. Early diagnosis, termination of pregnancy as soon as possible, multidisciplinary collaboration and active and effective supportive care are the keys to improve the prognosis of maternal and child. Refer to the treatment as soon as possible when conditions do not exist.