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目的:探讨兰索拉唑(LAN)与奥美拉唑(OME)治疗胃溃疡的临床效果及对患者血浆氧化应激水平和血管内皮功能的影响。方法:选取我院2014年1月~2016年10月收治的138例胃溃疡患者,按照随机数字表法均分为LAN组和OME组,并选取我院同期69例健康体检者为对照组。对照组不用任何药物,LAN组予以LAN治疗,OME组给予OME治疗。记录比较LAN组和OME组的临床疗效、Hp根除率及胃镜疗效;对照组与LAN组、OME组两组治疗前后血浆氧化应激指标、血管内皮功能指标水平;并评价LAN组与OME组的用药安全性。结果:总疗程结束后,LAN组总有效率、Hp根除率分别为94.2%、89.9%,较OME组(91.3%、87.0%)相比差异无统计学意义(P>0.05)。经4个疗程后,LAN组胃镜总有效率为95.7%,明显高于OME组的85.5%(P<0.05)。与对照组相比,LAN组、OME组治疗前血浆MDA、ET-1水平均显著上升(P<0.01),SOD、NO水平均显著降低(P<0.01)。与本组治疗前对比,LAN组、OME组治疗后血浆MDA、SOD、NO及ET-1水平均显著改善(P<0.01),且LAN组治疗后各血浆因子水平改善效果均显著优于OME组(P<0.01)。结论:LAN治疗胃溃疡改善患者临床症状、根除Hp的效果及安全性与OME相当,但LAN更能有效降低机体的氧化应激水平,调节血管内皮功能,促进溃疡愈合。
Objective: To investigate the clinical effects of lansoprazole (LAN) and omeprazole (OME) on gastric ulcer and its effect on plasma oxidative stress and endothelial function. Methods: One hundred and thirty-eight gastric ulcer patients admitted from January 2014 to October 2016 in our hospital were randomly divided into LAN group and OME group according to random number table method. 69 healthy subjects in our hospital were selected as the control group. The control group without any drugs, LAN group LAN treatment, OME group OME treatment. The clinical efficacy, Hp eradication rate and gastroscopic efficacy of LAN and OME groups were compared and recorded. Plasma oxidative stress index and vascular endothelial function index were compared between the two groups before and after treatment in the control group, LAN and OME groups. Medication safety Results: After the end of the total course of treatment, the total effective rate and the eradication rate of Hp in the LAN group were 94.2% and 89.9%, respectively, which were not significantly different from those in the OME group (91.3% and 87.0%) (P> 0.05). After 4 courses of treatment, the total effective rate of gastroscopy in LAN group was 95.7%, which was significantly higher than that in OME group (85.5%, P <0.05). Compared with the control group, plasma MDA and ET-1 levels in both LAN and OME groups increased significantly (P <0.01), and SOD and NO levels decreased significantly (P <0.01). Compared with the group before treatment, the levels of plasma MDA, SOD, NO and ET-1 in LAN and OME groups were significantly improved (P <0.01), and the improvement effect of each plasma factor level in LAN group was better than OME Group (P <0.01). Conclusion: LAN treatment of gastric ulcer to improve clinical symptoms, eradication of Hp effect and safety and OME, but LAN is more effective in reducing the body’s oxidative stress levels, regulating vascular endothelial function and promote ulcer healing.