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目的介绍和阐述诺氏(Naranjo’s)评估量表在药物不良反应评价中的作用。方法查阅近年相关研究报道,结合实例阐述诺氏评估量表在药物不良反应评价中的作用。结果诺氏评估量表由事先设置既定分值的10个医学相关问题构成,主要用于评价和确定药物使用与药物不良反应之间的相关性。根据诺氏评估量表可明确将药物不良反应划分为“确定的(defi-nite)”、“很可能的(probable)”、“可能的(possible)”、“可疑的(doubtful)”等4类,并附各项下具体分值及医学意义的独立问题。结论诺氏评估量表简便实用、准确可信,是药物不良反应研究的有效工具,对评估和确定药物使用与药物不良反应之间的因果关系具有重要作用。
Objective To introduce and explain the role of Naranjo’s assessment scale in the evaluation of adverse drug reactions. Methods Refer to relevant research reports in recent years, combined with examples to illustrate the role of the Nobel assessment scale in the evaluation of adverse drug reactions. Results The Knoitz assessment scale consisted of 10 medically related questions with set scores set in advance and was used primarily to evaluate and determine the association between drug use and adverse drug reactions. According to the Nordstrom scale, adverse drug reactions can be categorized as “defi-nite,” “probable,” “possible,” and “suspect.” (Doubtful) "and other four categories, with specific points under the various items and the medical issue of independence. Conclusions The Nob value scale is simple and practical, accurate and credible, which is an effective tool for the study of adverse drug reactions. It plays an important role in assessing and determining the causal relationship between drug use and adverse drug reactions.