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给大鼠一次气管注入氰戊菊酯悬液(FS)以及中毒室内吸入氰戊菊酯(FA),通过分析BALF中细胞与生化组分评价肺脏的毒性反应。结果表明PAM_s数下降,PMN数、Alb和NANA含量增加,LDH、ALP和ACP活性升高,提示氰戊菊酯引起肺细胞生物膜损伤、弥漫性肺泡炎和肺水肿。氰戊菊酯的阈剂量和阈浓度分别为0.93 mg/kg和200 mg/m~3,阈下剂量和阈下浓度为0.19 mg/kg和40 mg/m~2。研究结果为探讨氰戊菊酯的肺脏毒性及其机理,为制订其卫生标准提供依据。
Rats were given a single intratracheal injection of fenvalerate suspension (FS) and inhalation of fenvalerate (FA) in the poisoning chamber. The toxicity of lungs was evaluated by analyzing the cells and biochemical components in BALF. The results showed that PAM_s number decreased, PMN number, Alb and NANA content increased, LDH, ALP and ACP activity increased, suggesting that fenvalerate caused lung cell biofilm damage, diffuse alveolitis and pulmonary edema. The threshold and threshold concentrations of fenvalerate were 0.93 mg / kg and 200 mg / m 3, respectively. The subthreshold and subthreshold concentrations were 0.19 mg / kg and 40 mg / m 2, respectively. The results of the study to explore the toxicity of fenvalerate and its mechanism of lung for the development of health standards to provide the basis.