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目的探讨慢性乙型肝炎(CHB)患者病毒相关因素对代谢参数的影响。方法分析110例CHB患者不同乙肝病毒(HBV)携带年限组、不同HBV DNA病毒载量组各项代谢参数的差异。结果 1)胰岛素抵抗指数(HOMA-IR)及空腹血糖(FPG)随着HBV携带年限延长而升高,差异有统计学意义(P<0.05);2)与其他HBV DNA水平组比较,HBV DNA≥108 uIU/mL组总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-c)水平更高,HBV DNA在10~3~10~5组肝脂肪化比例更高,差异有统计学意义(P<0.05)。结论 CHB患者HBV携带年限、病毒载量均对代谢参数有影响:HBV携带年限越长越易导致胰岛素抵抗及糖代谢异常;病毒载量高易导致脂代谢异常及肝脂肪化。
Objective To investigate the influence of virus-related factors on metabolic parameters in patients with chronic hepatitis B (CHB). Methods The differences of metabolic parameters among 110 CHB patients with different HBV HBV carriers and different HBV DNA viral load groups were analyzed. Results 1) The levels of insulin resistance index (HOMA-IR) and fasting plasma glucose (FPG) increased with the number of HBV carriers extended, the difference was statistically significant (P <0.05); 2) Compared with other HBV DNA group, The levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-c) were higher in the group of ≥108 uIU / mL, and the proportion of hepatic steatosis was higher in the group of 10 ~ 3 ~ 10 ~ 5 HBV DNA P <0.05). Conclusion HBV carriers and viral load in CHB patients all affect the metabolic parameters. The longer the HBV carrier life, the more likely it is to lead to insulin resistance and abnormal glucose metabolism. The higher viral load may lead to abnormal lipid metabolism and hepatic steatosis.