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在各种淋巴增生紊乱的组织和包括正常神经元在内的胚胎和成人组织中,都有对B细胞白血病/淋巴瘤-2基因(bcl-2)产物的免疫反应性,最近发现,在一些神经母细胞瘤组织层中亦有。作者检查了34例神经母细胞瘤及节细胞神经母细胞瘤病人的46个标本,它们包含了各临床阶段和所有病灶。在检查中发现,无论是来自1期还是4期、原发灶还是继发灶、化疗前还是化疗后的组织标本,都有对bcl-2的免疫反应性。而未分化的神经母细胞
Immunoreactivity to B cell leukemia / lymphoma-2 gene (bcl-2) products has been found in a variety of lymphoproliferative disorders and in embryonic and adult tissues, including normal neurons, There are also neuroblastoma tissue layers. The authors examined 46 specimens from 34 patients with neuroblastoma and ganglioneuroblastoma, which included all clinical stages and all lesions. Found in the examination, either from stage 1 or 4, the primary tumor or secondary tumor, before chemotherapy or after chemotherapy tissue samples, have immune response to bcl-2. While undifferentiated neuroblasts