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目的 探讨中国人缺血性脑卒中与凝血因子 (F )基因 arg35 3g1n及 del(- 32 3) ins多态性的关系。方法 利用 PCR技术和分子杂交技术对北京地区 2 94例缺血性脑卒中患者进行 F 基因 arg35 3g1n及 del(- 32 3) ins多态性的检测和分析 ,并与 2 79例北京地区的非卒中对照进行比较。结果 缺血性脑卒中患者 F 基因 arg35 3g1n及 del(- 32 3) ins多态性的基因型频率和等位基因频率与对照组相比无明显差异。结论 F 基因arg35 3g1n及 del(- 32 3) ins多态性可能不是中国人群缺血性脑卒中发病的遗传学危险因素。
Objective To investigate the relationship between ischemic stroke and the arg35 3g1n and del (- 32 3) ins polymorphisms in Chinese people. Methods The polymorphisms of arg35 3g1n and del (- 32 3) ins of F gene in 2 94 ischemic stroke patients in Beijing were detected and analyzed by PCR and molecular hybridization. The results were compared with those of 2 79 cases of non - Stroke controls were compared. Results The frequencies of genotypes and alleles of arg35 3g1n and del (- 32 3) ins polymorphisms in ischemic stroke patients were not significantly different from those in control subjects. Conclusion The polymorphisms of arg35 3g1n and del (- 32 3) ins may not be the genetic risk factors of ischemic stroke in Chinese population.