糖尿病视网膜病变（DR）是糖尿病的主要微血管并发症，其主要病理改变为视网膜微血管渗漏、血管新生等。6-磷酸果糖激酶-2／2，6双磷酸激酶同工酶3（PFKFB3）作为糖酵解的关键酶，在血管内皮细胞中高表达，当受到低氧、炎症刺激因子、生长因子等因素刺激时其表达上调并对血管内皮细胞的能量代谢发挥重要的调节作用。近期研究发现 PFKFB3可通过促进糖酵解、加快细胞周期、抑制细胞凋亡等多种途径促进细胞的增殖，同时通过影响内皮细胞的伪足生成、亚型分化等过程促进细胞的迁移，在以上两个过程的作用下加速血管新生的进程，从而促进 DR 的发生发展。“,”Diabetic retinopathy (DR)is one of major microvascular complications of diabetes melli-tus.DR is mainly pathologically characterized with retinal microvascular leakage and angiogenesis,etc.As a key enzyme during glycolysis,6-phosphofructo-2-kinase /fructose-2,6-bisphosphatase-3 (PFKFB3)is highly expressed in vascular endothelial cells.The expression of PFKFB3 is up-regulated by hypoxia,inflammatory cytokines and growth factor,and plays a vital role in regulating the energy metabolism of vascular endothelial cells.Recent researches have demonstrated that PFKFB3 may accelerate cell proliferation via promoting glycol-ysis,accelerating cell cycle and suppressing cell apoptosis,etc.Meantime,PFKFB3 could promote cell miti-gation through affecting the filopodia formation and subtype differentiation of endothelial cells.These activities can accelerate the progress of angiogenesis,thereby promoting the occurrence and progression of DR.