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肿瘤转移抑制基因的表达产物——转移消失蛋白是一种肌动蛋白结合蛋白,广泛表达于多种组织,而在转移性肿瘤中,其表达缺失。在细胞发生发展以及肿瘤的侵袭和转移中,MTSS1发挥着重要作用。着重从肿瘤转移抑制基因的结构、生物学功能以及其与肿瘤转移的关系做一综述。
The expression product of tumor metastasis suppressor-transfer-loss protein is an actin-binding protein that is widely expressed in many tissues but is absent in metastatic tumors. MTSS1 plays an important role in cell development and tumor invasion and metastasis. This review focuses on the structure, biological function of tumor suppressor genes and their relationship with tumor metastasis.