女患,52岁,未婚。因Cushing’病26年,糖尿病25年,于1993年3月19日入院。1966年初因肥胖、皮肤紫纹及血压升高,诊为皮质醇增多症。1967年3月行右侧肾上腺次全切除术。同时发现血糖升高诊为继发性糖尿病,给予优降糖、D_(860)治疗,血糖波动于9～10.9mmol/L。于1971年行左侧肾上腺部分切除术。1981年因垂体微腺瘤用钴照射治疗。1982年改用普通胰岛素(60u/日)治疗糖尿病。由于血糖控制差,自 Female, 52 years old, unmarried. Because of Cushing ’s disease for 26 years and diabetes for 25 years, she was admitted on March 19, 1993. Early 1966 due to obesity, skin purple pattern and blood pressure, diagnosed as Cushing’s syndrome. In March 1967 the right subtotal adrenalectomy. Also found that elevated blood glucose was diagnosed as secondary diabetes, given glyburide, D_ (860) treatment, blood glucose fluctuations in 9 ~ 10.9mmol / L. In 1971 left partial adrenalectomy. In 1981 due to pituitary adenoma irradiation with cobalt treatment. In 1982 switch to ordinary insulin (60u / day) for the treatment of diabetes. Because of poor glycemic control, since