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目的为给疫区人群长期服用青蒿琥酯的安全性提供实验依据。方法人白鼠分别每周１次喂服 １２０、６０、３０ｍｇ／ｋｇ的青蒿琥酯，连续 ６个月，于喂药中期间个月）、最后 １次给药后 １。ｄ及停药后２周，对人白鼠的外观、一般症状、体重、血液学、血清生化学指标及病理学等进行观察。结果 各实验组在服药前后的外观、体征、行为活动和粪便等均无明显异常，各项指标均在正常范围，各服药组与对照组比较无显著性差异（Ｐ＞０．０５）；病理学检查未见异常。结论口服使用青蒿琥酯具有较好的安全性。
Objective To provide long-term use of artesunate in infected areas to provide experimental evidence of the safety. Methods The human white rats were fed with 120, 60 and 30 mg / kg of artesunate once a week for 6 months continuously for one month during the course of feeding. d and 2 weeks after drug withdrawal, the appearance, general symptoms, body weight, hematology, serum biochemical indexes and pathology of human white mice were observed. Results The appearance, signs, behavior and stool of each experimental group had no obvious abnormalities before and after taking the medicine. All the indexes were in the normal range. There was no significant difference between the two groups (P> 0.05) No abnormalities in physical examination. Conclusion Oral use of artesunate has good safety.