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肿瘤坏死因子（ｔｕｍｏｒｎｅｃｒｏｓｉｓｆａｃｔｏｒ，ＴＮＦ）是内毒素诱导肺动脉高压（ｐｕｌｍｏｎａｒｙａｒｔｅｒｙｈｙｐｅｒｔｅｎｓｉｏｎ，ＰＡＨ）的重要前炎症介质，给动物单独注入ＴＮＦ－α也可引起于内毒素血症中所见到的ＰＡＨ，但其机制尚未完全明了...
Tumor necrosis factor (TNF), an important proinflammatory mediator of endotoxin-induced pulmonary arterial hypertension (PAH), can also cause PAH seen in endotoxemia by injecting TNF-α alone. However, the mechanism Not yet fully understood ...