Moving vehicle loads, associated with roadway traffic can induce significant dynamic effects on the structural behaviours of bridges, especially for long-span bridges. The main objective of current research is to study traffic induced dynamic responses of long-span box-girder bridges. The finite element method has been employed in this study to obtain a three-dimensional mathematical model for the bridge system. For vehicle-bridge dynamic interaction analysis, the vehicle is modeled as a more realistic three-axle, six-wheel system, and the corresponding dynamic interaction equations have been derived. The bridge-vehicle interaction is affected by many factors. The current study has been focused on such factors as: vehicle speed, vehicle damping ratio, multiple traffic lanes, mass ratio of vehicle and bridge, and dynamic characteristics of bridge. Case studies have been conducted to investigate these factors by using several box girder bridge examples including Confederation Bridge, the longest box girder bridge in the world. Moving vehicle loads, associated with roadway traffic can induce significant dynamic effects on the structural behaviors of bridges, especially for long-span bridges. The main objective of current research is to study traffic induced dynamic responses of long-span box-girder bridges. The finite element method has been employed in this study to obtain a three-dimensional mathematical model for the bridge system. For vehicle-bridge dynamic interaction analysis, the vehicle is modeled as a more realistic three-axle, six-wheel system, and the corresponding The current study has been focused on such factors as: vehicle speed, vehicle damping ratio, multiple traffic lanes, mass ratio of vehicle and bridge, and dynamic characteristics of bridge. Case studies have been conducted to investigate these factors by using several box girder bridge examples including Confederation Bridge, the longest box girder bridge in the world.