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放射医学中氧效应的研究很早就已提出,放射敏感性与氧状态有关也早已被人们所公认,近来,国外对低氧的放射生物学效应开展了研究,证明低氧具有保护正常组织,减轻放射反应和降低并发症,提高免疫功能的作用。70年代末期苏联创立了《低氧放射疗法》对治癌的效果进行了试验研究,现将有关情况综述如下: (一) 低氧的放射生物学效应 1984年苏联放射生物学家克·依卡尔梅柯夫及其同事采用深度缺氧的方法观察了放射对小鼠的生物学效应,他们在研究中采用2.75Gy剂量的中子射线照射小鼠,结果发现在空气中照射的全部死亡,而在低氧环境中照射仅死亡36％,呼吸空气和呼吸低氧气体的动物存活率存在明显的差别。缺氧和正
The study of oxygen effects in radiation medicine has long been proposed, and radiosensitivity has long been recognized in relation to oxygen status. Recently, research on the radiobiological effects of hypoxia has been conducted in overseas countries, demonstrating that hypoxia protects normal tissues. Reduce radiation reactions and reduce complications and improve immune function. In the late 1970s, the Soviet Union established “Hypoxia Radiation Therapy” to test the effects of cancer treatment. The current situation is summarized as follows: (1) Radiobiological effects of hypoxia. 1984 Soviet radiobiologist Ke Ikar Mekov and his colleagues observed the biological effects of radiation on mice using a method of deep hypoxia. They used a 2.75 Gy dose of neutron radiation to irradiate mice. They found that all of the radiation in the air died. In the hypoxic environment, only 36% of the animals died. There was a significant difference in the survival rate of animals breathing air and breathing hypoxic gases. Hypoxia and positive