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作者报告8例用~(32)P治疗本病的经验.其中4例在发生出血后而诊断,余下者是述不明原因的疲乏、不适后经查血偶然发现而确诊.静脉给~(32)P为111～222M Bq(3～6mCi),平均157.25MBq(4.25mCi).血小板计数在治疗后头三个月每月查一次,此后间隔三个月一次.治疗前血小板平均值为1100×10~9/L,首次注入~(32)P后最低值为550×10~9/L.8例中5例后来需给~(32)P以维持血小板计数<600×10~9/L.在第二次注入后血小板下降率未发现有何差别.2例需多次注入~(32)P,但后来每次注射其血小板下降率未减少.3例在多次注射后因持续性血小板增高而需化疗,无临床或血液学方面的特性改变,仅1例在诊断本病后3年发生非特异性白血病.
The authors report 8 patients with ~ (32) P experience in the treatment of this disease, of which 4 were diagnosed after hemorrhage, the rest were unexplained fatigue, discomfort after blood was diagnosed by accidental diagnosis. ) P was 111 ~ 222M Bq (3 ~ 6mCi) with an average of 157.25MBq (4.25mCi) .Platelet count was checked monthly for the first trimester after treatment and then once every three months after treatment.The average value of platelet before treatment was 1100 × 10 ~ 9 / L, after the first injection of ~ (32) P, the lowest value was 550 × 10 ~ 9 / L. In 5 of 8 patients, ~ (32) P was needed to maintain platelet count <600 × 10 ~ 9 / L. There was no difference in the rate of thrombocytopenia after the second injection.2 cases required multiple injections of ~ (32) P, but no decrease in the rate of thrombocytopenia was observed after each injection.3 cases of persistent thrombocytopenia Increased and required chemotherapy, no clinical or hematological changes in the characteristics of only 1 case of non-specific leukemia after 3 years of diagnosis of this disease.