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通过免疫组织化学方法研究了４种胎盘蛋白（ＰＰ１１、ＰＰ１９ＰＰ２５和ＰＰ２６）在滋养细胞肿瘤中的表达情况。发现ＰＰ１１在恶性葡萄胎中的表达明显低于葡萄胎（Ｐ＜０．０５），ＰＰ２５和ＰＰ２６在绒癌中的表达低于葡萄胎（Ｐ＜０．０５），ＰＰ１９在各种滋养细胞肿瘤中皆有强表达，提示联合检测４种胎盘蛋白有助于滋养细胞肿瘤间的鉴别诊断。ＰＰ１９还是中间型滋养细胞肿瘤的优良标志物。
The expression of four placental proteins (PP11, PP19PP25, and PP26) in trophoblastic tumors was studied by immunohistochemistry. The expression of PP11 in malignant moles was significantly lower than that in hydatidiform moles (P<0.05). The expression of PP25 and PP26 in choriocarcinoma was lower than that in hydatidiform mole (P<0.05). PP19 was found in various trophoblastic tumours. Both of them have strong expression, suggesting that the combined detection of four kinds of placental proteins contributes to differential diagnosis between trophoblastic tumors. PP19 is also an excellent marker of intermediate trophoblastic tumors.