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通过免疫组织化学方法研究了4种胎盘蛋白(PP11、PP19PP25和PP26)在滋养细胞肿瘤中的表达情况。发现PP11在恶性葡萄胎中的表达明显低于葡萄胎(P<0.05),PP25和PP26在绒癌中的表达低于葡萄胎(P<0.05),PP19在各种滋养细胞肿瘤中皆有强表达,提示联合检测4种胎盘蛋白有助于滋养细胞肿瘤间的鉴别诊断。PP19还是中间型滋养细胞肿瘤的优良标志物。
The expression of four placental proteins (PP11, PP19PP25, and PP26) in trophoblastic tumors was studied by immunohistochemistry. The expression of PP11 in malignant moles was significantly lower than that in hydatidiform moles (P<0.05). The expression of PP25 and PP26 in choriocarcinoma was lower than that in hydatidiform mole (P<0.05). PP19 was found in various trophoblastic tumours. Both of them have strong expression, suggesting that the combined detection of four kinds of placental proteins contributes to differential diagnosis between trophoblastic tumors. PP19 is also an excellent marker of intermediate trophoblastic tumors.