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为了快速检测非整倍体诱发剂，我们应用体外培养淋巴细胞微核检测法，根据非整倍体诱发剂与染色体断裂剂诱发的微核形成于不同的细胞周期来评估非整倍体诱发剂。结果表明，（１）非整倍体诱发剂ＶＣＲ与染色体断裂剂ＭＭＣ相比，在药物处理后７小时引起微核率显著上升；（２）与对照组相比，ＶＣＲ处理后５、７ｈ引起微核率显著性升高，以７ｈ的微核检出率最高；而ＭＭＣ处理组在处理后各个时间的微核率与对照组相比均无显著性差异。本实验结果提示，在两类诱变剂ＶＣＲ、ＭＭＣ处理后７ｈ，就可快速地区别出非整倍体诱发剂与染色体断裂剂。
In order to rapidly detect aneuploid inducer, we use micronucleus test of lymphocytes in vitro to evaluate the effect of aneuploidy inducer and micronuclei induced by chromosome rupture on different cell cycle . The results showed that: (1) Compared with the chromosomal cleavage agent (MMC), VCR induced by aneuploidy induced a significant increase of micronucleus rate at 7 hours after drug treatment; (2) Compared with the control group, VCR induced 5,7h The micronucleus rate was significantly increased, with the highest detection rate of micronuclei at 7h. However, there was no significant difference in micronucleus rate between MMC and control groups after treatment. The experimental results suggest that in two types of mutagen VCR, MMC treatment 7h, you can quickly distinguish between aneuploidy inducer and chromosome rupture agent.