Objective: To observe the curative effect of release with needle knife combined with microporous decompression in bone marrow edema area of subchndral bone for treatment of knee osteoarthritis.Method: From March 2019 to March 2020, 66 patients with knee osteoarthritis were selected as the research objects, and divided into treatment group and control group according to random nuber table. The treatment group was treated with release with needle knife combined with microporous decompression in bone marrow edema area, while the control group was treated with release with needle knife. Visual analogue scale (VAS), the Western Ontario and McMaster University composite index (WOMCA) and inflammatory factors were used to evaluate the curative effect of patients before treatment and after treatment.Results: The VAS scores of knee pain in both groups decreased after treatment. The treatment group was lower than the control group. The WOMAC scores of both groups were decreased significantly after treatment, and then gradually decreased with time.The WOMAC scroes of the treatment group were lower than those of the control group after treatment,and there was an interactive effect on time factor. Conclusion: Release with needle knife combined with microporous decompression in bone marrow edema area of subchondral bone has good curative effect in the treatment of knee osteoarthritis; it can relieve the pain of patients, improve the function of joint, reduce inlfammatory reaction,and then delay the pathological progress of KOA,which is worthy of clinical promotion.