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Ｌ－２－氧－４－噻唑烷酸（Ｌ－ＯＴＣ）是细胞内Ｌ－半胱氨酸的一个优良前体药，也是合成谷胱甘肽（ＧＳＨ）的有效刺激剂，对机体无毒性［１］。Ｗｉｌｉａｍｓｏｎ等报道，Ｌ－ＯＴＣ可使正常小鼠肝组织的ＧＳＨ水平明显升高，可使对－乙酰氨基酚（Ｐ－ＡＰ）中毒小鼠...
L-2-oxo-4-thiazolidine acid (L-OTC) is an excellent pro-drug of intracellular L-cysteine and is also a potent stimulator of glutathione synthesis (GSH) [1]. Wiliamson et al reported that L-OTC can significantly increase the level of GSH in the normal mouse liver tissue, which can make the paracetamol (P-AP) poisoned mice ...