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目的：用乙基亚硝基脲（ＥＮＵ）对ｘｙ１Ｅ／ＩＣＲ转基因小鼠进行致突变试验，进一步验证该动物模型在体内基因突变研究中的应用价值，为今后的推广应用奠定基础。方法：以１／１０ＬＤ５０剂量的ＥＮＵ连续５次腹腔注射的方式对ｘｙ１Ｅ／ＩＣＲ转基因小鼠进行诱变处理，在
OBJECTIVE: To study the mutagenicity of xy1E / ICR transgenic mice with ethyl nitrosourea (ENU) to further verify the value of this animal model in the study of gene mutation in vivo, which will lay the foundation for its future application. Methods: The xy1E / ICR transgenic mice were mutagenized with 1 / 10LD50 doses of ENU for 5 consecutive intraperitoneal injections.