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28名患者在服用维持量地高辛(平均剂量为0.25mg/天)的同时,并用乙胺碘呋酮(600～1800mg/天)1～3周。采集血样并分析其药物浓度。结果发现,在合并用药期间,地高辛的平均血清浓度从0.97增加至1.98ng/ml。
28 patients received amiodarone (600-1800 mg / day) for 1 to 3 weeks while taking the maintenance dose of digoxin (mean dose of 0.25 mg / day). Blood samples were collected and analyzed for drug concentration. As a result, it was found that the mean serum digoxin concentration increased from 0.97 to 1.98 ng / ml during the combination therapy.