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目的探讨深吸气量(inspiratory capacity,IC)与慢性阻塞性肺疾病(chronic obstructive pulmonarydisease,COPD)患者临床特征的相关性。方法 2009年12月2010年6月纳入84例稳定期COPD患者,测定6分钟步行试验(6-minute walk test,6MWT)、圣乔治生活问卷评分(St George′s respiratory questionnaire,SGRQ)及肺功能检查:第1秒用力呼气容积(forced expirotovy volume in one second,FEV1)、IC、IC与肺总量(total lung capacity,TLC)比值(IC/TLC)等相关指标,并进行相关性分析。结果 6MWT值与FEV1无明显直线相关(r=0.14,P>0.1);6MWT值与FEV1≥60%无明显直线相关(r=0.16,P>0.1);6MWT值与IC值呈正的直线相关(r=0.317,P<0.01);6MWT值与IC/TLC值呈正的直线相关(r=0.274,P<0.01);SGRQ值与FEV1呈负的直线相关(r=-0.307,P<0.01);SGRQ值与IC值无直线相关(r=-0.001,P>0.25);SGRQ值与IC/TLC值无直线相关(r=-0.003,P>0.25)。结论对COPD患者,IC比FEV1更准确地反映患者的运动耐量的程度,FEV1比IC更准确地反映患者呼吸困难的严重程度。
Objective To investigate the correlation between inspiratory capacity (IC) and clinical features in patients with chronic obstructive pulmonary disease (COPD). Methods December 2009, June 2010 Eighty-four patients with stable COPD were enrolled in the study. Six-minute walk test (6MWT), St George’s respiratory questionnaire (SGRQ) and pulmonary function The levels of forced expirotovy volume in one second (FEV1), IC, IC (total lung capacity, TLC) ratio and other related indicators were examined and the correlations were analyzed. Results There was no significant linear correlation between 6MWT and FEV1 (r = 0.14, P> 0.1), 6MWT and FEV1≥60% (r = 0.16, P> 0.1) (r = -0.307, P <0.01). There was a positive linear relationship between 6MWT and IC / TLC (r = 0.274, P <0.01); SGRQ was negatively correlated with FEV1 There was no linear correlation between SGRQ value and IC value (r = -0.001, P> 0.25). There was no linear correlation between SGRQ value and IC / TLC value (r = -0.003, P> 0.25). Conclusion In patients with COPD, IC more accurately reflects the degree of exercise tolerance in patients than FEV1. FEV1 reflects the severity of dyspnea in patients more accurately than IC.