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目的探讨依达拉奉注射液联合单唾液酸四己糖神经节苷脂钠注射液治疗急性脑梗死的临床疗效。方法选取2014年1月—2015年7月南京医科大学附属苏州市立医院收治的急性脑梗死患者99例,根据用药方案不同分为观察组51例与对照组48例。对照组患者予以单唾液酸四己糖神经节苷脂钠注射液治疗,观察组患者在对照组基础上加用依达拉奉注射液治疗。观察两组患者临床疗效、日常生活能力及不良反应发生情况。结果观察组患者总有效率高于对照组,日常生活能力评分高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论依达拉奉注射液联合单唾液酸四己糖神经节苷脂钠注射液治疗急性脑梗死的临床疗效显著,可改善患者日常生活能力及神经功能,且不良反应少。
Objective To investigate the clinical efficacy of edaravone injection and monosialotetrahexosyl ganglioside sodium injection in the treatment of acute cerebral infarction. Methods From January 2014 to July 2015, 99 patients with acute cerebral infarction admitted to Suzhou Municipal Hospital Affiliated to Nanjing Medical University were divided into observation group (n = 51) and control group (n = 48) according to different dosage regimen. Patients in the control group were treated with monosialotetrahexosyl ganglioside sodium injection. Patients in the observation group were treated with edaravone injection on the basis of the control group. The clinical efficacy, daily living ability and adverse reactions of the two groups were observed. Results The total effective rate in observation group was higher than that in control group, and the daily living ability score was higher than that in control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05 ). Conclusion Edaravone injection combined with monosialotetrahexosyl ganglioside sodium injection in the treatment of acute cerebral infarction has significant clinical curative effect, which can improve patients’ daily living ability and nerve function with less adverse reactions.