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目的探讨支原体肺炎儿童的免疫功能变化情况,为临床儿童支原体肺炎的诊治提供依据。方法选择2013年1月-2014年12月在浙江绿城心血管病医院儿科被诊断为支原体肺炎的儿童55例作为实验组,同期儿童作为对照组,实验组根据病情分为重症型和非重症型。分析支原体肺炎患儿和对照组儿童的CD4+、CD8+和CD4+/CD8+检测情况、血清Ig G、Ig A和Ig M监测情况以及血清IL-10、IL-8、IL-2检测情况。结果支原体肺炎患儿急性期和恢复期的CD4+和CD4+/CD8+均明显低于对照组(P<0.05),急性期的CD4+和CD4+/CD8+均明显低于恢复期(P<0.05);急性期和恢复期的CD8+明显高于对照组(P<0.05),急性期的CD8+明显高于恢复期(P<0.05)。支原体肺炎患儿重症型的CD4+和CD4+/CD8+明显低于非重症型(P<0.05),支原体肺炎患儿重症型的CD8+明显高于非重症型(P<0.05)。支原体肺炎患儿急性期的Ig A和Ig M均明显高于对照组(P<0.05),恢复期的Ig G、Ig A和Ig M均明显高于急性期和对照组(P<0.05)。支原体肺炎患儿重症型的Ig G、Ig A和Ig M明显高于非重症型(P<0.05)。支原体肺炎患儿急性期的IL-10和IL-2均明显低于恢复期和对照组(P<0.05),急性期的IL-8明显高于恢复期和对照组(P<0.05);恢复期的IL-2均明显低于对照组(P<0.05),恢复期的IL-8明显高于对照组(P<0.05)。支原体肺炎患儿重症型的IL-10和IL-2明显低于非重症型(P<0.05),支原体肺炎患儿重症型的IL-8明显高于非重症型(P<0.05)。结论在支原体肺炎患儿中存在细胞免疫、体液免疫和细胞因子等免疫功能的异常,免疫功能在支原体肺炎中发挥重要作用。
Objective To investigate the changes of immune function in children with mycoplasma pneumonia and provide evidence for the diagnosis and treatment of children with mycoplasma pneumonia. Methods From January 2013 to December 2014, 55 children with mycoplasma pneumonia were diagnosed as Pediatric pneumonia in Zhejiang Greentown Cardiovascular Hospital as experimental group and children as control group. The experimental group was divided into severe and non-severe type . The detection of CD4 +, CD8 + and CD4 + / CD8 + in children with mycoplasma pneumonia and control group, the detection of serum Ig G, Ig A and Ig M and the detection of serum IL-10, IL-8 and IL-2. Results The levels of CD4 + and CD4 + / CD8 + in acute and convalescent children with mycoplasma pneumonia were significantly lower than those in the control group (P <0.05). The acute CD4 + and CD4 + / CD8 + And convalescent CD8 + were significantly higher than those in control group (P <0.05). CD8 + in acute phase was significantly higher than that in convalescent phase (P <0.05). Children with mycoplasma pneumonia severe type of CD4 + and CD4 + / CD8 + was significantly lower than non-severe type (P <0.05), severe mycoplasma pneumonia in children with severe CD8 + was significantly higher than non-severe type (P <0.05). IgA and Ig M in children with mycoplasma pneumonia at acute stage were significantly higher than those in control group (P <0.05). IgG, IgA and Ig M in recovery stage were significantly higher than those in acute stage and control group (P <0.05). Mycoplasma pneumonia in children with severe type of Ig G, Ig A and Ig M was significantly higher than non-severe type (P <0.05). IL-10 and IL-2 levels in children with mycoplasma pneumonia were significantly lower than those in recovery and control groups (P <0.05), IL-8 in acute phase was significantly higher than those in recovery and control groups (P <0.05) The levels of IL-2 in the two groups were significantly lower than those in the control group (P <0.05). IL-8 in the recovery phase was significantly higher than that in the control group (P <0.05). The severe IL-10 and IL-2 in children with mycoplasma pneumonia were significantly lower than those in non-severe type (P <0.05). The severe IL-8 in children with mycoplasma pneumonia was significantly higher than that in non-severe type (P <0.05). Conclusion There are abnormal immune functions such as cellular immunity, humoral immunity and cytokines in children with mycoplasma pneumonia. Immune function plays an important role in mycoplasma pneumonia.