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报道将氟尿嘧啶软膏改制成乳膏剂型(O/W),处方中加入新型的促透皮吸收辅料月桂氮酮(Azonc),并对改制后的制剂做了质量稳定性实验,采用吸收系数法测定乳膏中5-Fu的含量,平均回收率为102,38%,CV为1.52%.
It is reported that fluorouracil ointment is converted into ointment (O / W), a new type of transdermal absorbable excipient Azone (Azonc) is added into the prescription, and the quality stability test of the prepared preparation is made. The absorption coefficient method The 5-Fu content in the cream, the average recovery was 102,38%, CV was 1.52%.