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目的观察E838及其与化疗药物环磷酰胺(CTX)联合应用对白血病L1210细胞荷瘤小鼠的肿瘤抑制及生命延长作用。方法以L1210荷瘤IRM-2小鼠为模型,实验分对照组、CTX组、E838组、E838+CTX组,分别检测肿瘤抑制率、骨髓有核细胞数、胸腺与脾指数、生命延长率等指标,比较各组间的差别。结果E838治疗组瘤重明显小于对照组,联合用药组对荷瘤小鼠白血病L1210有较强抑制作用。生命延长也有提高作用。结论E838对白血病L1210有抑制作用,与化疗药物CTX合用时,能提高疗效及机体免疫功能。
Objective To observe the inhibitory effect of E838 and its combination with cyclophosphamide (CTX) on the tumor suppression and life prolongation of leukemia L1210 tumor-bearing mice. Methods L1210 tumor-bearing IRM-2 mice were used as the model. The experimental groups were divided into control group, CTX group, E838 group and E838 + CTX group. The tumor inhibition rate, number of bone marrow nucleated cells, thymus and spleen index, Indicators to compare the differences between groups. Results The tumor weight of E838 treatment group was significantly less than that of the control group, and the combination therapy group had a stronger inhibitory effect on the tumor-bearing mouse leukemia L1210. Prolonged life can also improve. Conclusion E838 has an inhibitory effect on L1210 leukemia. When combined with chemotherapy drug CTX, E838 can improve efficacy and immune function.