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目的通过对行冠状动脉介入治疗患者造影剂肾病(CIN)发病情况的分析,探讨低渗非离子型造影剂对肾功能的影响及相关危险因素。方法 150例冠状动脉介入治疗患者,所有患者均应用低渗非离子型造影剂。术后2 d检测血肌酐水平,观察CIN的发生情况,比较CIN患者和非CIN患者年龄、造影剂量、造影前血肌酐以及肾功能不全、高血压、高血脂、高尿酸血症、糖尿病发生情况。结果 150例患者中发生CIN14例,发生率为9.33%。CIN组患者年龄、造影剂量及造影前血肌酐值均显著高于非CIN组患者,差异有统计学意义(P<0.01)。CIN组患者肾功能不全、高血压、高血脂、糖尿病发生率均高于非CIN组,差异具有统计学意义(P<0.05)。结论存在高龄、造影剂量大、造影前血肌酐水平较高等高危因素的患者CIN发病率高。原有肾功能不全、高血压、高血脂、糖尿病可能是CIN发生的危险因素。
Objective To analyze the incidence of contrast-induced nephropathy (CIN) in patients undergoing coronary intervention and to investigate the effect of hypotonic non-ionic contrast medium on renal function and related risk factors. Methods 150 cases of coronary intervention patients, all patients with hypotonic non-ionic contrast agent. The level of serum creatinine was measured 2 days after operation and the incidence of CIN was observed. The age, contrast dose, pre-contrast serum creatinine, renal insufficiency, hypertension, hyperlipidemia, hyperuricemia and diabetes mellitus were compared between CIN patients and non-CIN patients . Results 150 cases of CIN occurred in 14 cases, the incidence was 9.33%. The age of patients in CIN group, contrast dose and blood creatinine before angiography were significantly higher than those in non-CIN group, with significant difference (P <0.01). CIN patients with renal insufficiency, hypertension, hyperlipidemia, diabetes were higher than non-CIN group, the difference was statistically significant (P <0.05). Conclusions There is a high incidence of CIN in elderly patients, large contrast dose, and high risk serum creatinine before angiography. The original renal insufficiency, hypertension, hyperlipidemia, diabetes may be a risk factor for CIN.