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目的:探讨改进型实验性左侧精索静脉曲张(ELV)对大鼠血清卵泡刺激素(FSH)及抑制素B(InhB)的影响。方法:利用改进的方法建立青春期SD大鼠左精索静脉曲张的模型30只;假手术组SD大鼠30只作对照组。术后3个月,取大鼠血清,ELISA法分别检测FSH、InhB的浓度。结果:实验组大鼠血清中FSH浓度[(37.56±9.72)ng/ml]与对照组[(26.69±5.33)ng/ml]相比升高,具有统计学意义(P<0.05);而实验组大鼠血清中InhB的浓度[(349.93±99.48)pg/ml]与对照组[(768.83±146.96)pg/ml]相比下降,具有统计学意义(P<0.05)。结论:改进型ELV致FSH升高及InhB下降,这些变化可能是影响生育能力的机制之一。
Objective: To investigate the effect of modified experimental left varicocele (ELV) on serum FSH and InhB in rats. Methods: Thirty rabbits with left varicocele in adolescent SD rats were established by improved method. Thirty SD rats in sham operation group were used as control group. At 3 months after operation, rat serum and ELISA were used to detect the concentrations of FSH and InhB respectively. Results: Compared with control group [(26.69 ± 5.33) ng / ml], FSH concentration in serum of experimental group was significantly higher than that of control group [(37.56 ± 9.72) ng / ml] Compared with control group [(768.83 ± 146.96) pg / ml], the concentration of InhB in the serum of the rats in the group [(349.93 ± 99.48) pg / ml] was statistically significant (P <0.05). Conclusions: Elevated FSH and InhB decreased with improved ELV, and these changes may be one of the mechanisms that affect fertility.